LRRK2 links genetic and sporadic Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease.
Parkinson's disease (PD) is a complex neurodegenerative disorder whose aetiologies are largely unknown. To date, mutations in six genes have been found causal for some rare familial forms of the disease and common variation within at least three of these is associated with the more common sporadic forms of PD. LRRK2 is the most recently identified familial PD gene, although its role in sporadic...
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«If the clinician, as observer wishes to see things as they really are, he must make a tabula rasa of his mind and proceed without any preconceived notions whatever.»
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Hertie Institute of Clinical Brain Research, Department of Medical Genetics and Department of Neuroradiology, University of Tübingen, Tübingen, 4 Institute of Human Genetics, GSF National Research Institute, Neuherberg, Institute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Department of Neurology, University of Munich, Munich, Germany, Department of Neu...
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Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2019
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20180462